@article{ref1,
title="A functional polymorphism of the micro-opioid receptor gene is associated with completed suicides",
journal="Journal of neural transmission",
year="2008",
author="Hishimoto, A. and Cui, Huxing and Mouri, K. and Nushida, H. and Ueno, Y. and Maeda, K. and Shirakawa, O.",
volume="115",
number="3",
pages="531-536",
abstract="A recent linkage study suggested that a putative locus for suicidal behavior independent of psychiatric disease phenotypes lies at 5' upstream of the micro-opioid receptor (OPRM1) gene. We explored an association between suicide and genetic variations of the OPRM1 using a case-control study of 183 completed suicides and 374 control subjects. We genotyped four single nucleotide polymorphisms (SNPs) including a common A118G SNP. The genotypic and allelic distributions of the A118G SNP were significantly different between the completed suicide and control groups (P = 0.014 and 0.039, respectively). A dominant model analysis of the A118G SNP showed an enhanced association with suicide (P = 0.0041, Odds ratio 0.575) and this significant association was observed with a logistic regression analysis that takes sex and age factors into account (P = 0.021). Our results raise the possibility that the A118G SNP of the OPRM1 gene is associated with suicide.<p /> <p>Language: en</p>",
language="en",
issn="0300-9564",
doi="10.1007/s00702-007-0853-y",
url="http://dx.doi.org/10.1007/s00702-007-0853-y"
}