Citation

Kaltiainen HL, Liljeström M, Helle L, Salo A, Hietanen M, Renvall H, Forss N. J. Neurotrauma 2019; 36(14): 2222-2232.

Affiliation

University of Helsinki and Helsinki University Hospital, Department of Neurology, Helsinki, Finland ; nina.forss@hus.fi.

Copyright

(Copyright © 2019, Mary Ann Liebert Publishers)

DOI

10.1089/neu.2018.6306

PMID

30896274

Abstract

Despite the high prevalence of mild traumatic brain injury (mTBI), current diagnostic tools to objectively assess cognitive complaints after mTBI continue to be inadequate. Our aim was to identify neuronal correlates for cognitive difficulties in mTBI patients by evaluating the possible alterations in oscillatory brain activity during a behavioral task known to be sensitive to cognitive impairment after mTBI. We compared oscillatory brain activity during rest and cognitive tasks (Paced Auditory Serial Addition Test [PASAT] and a vigilance test [VT]) with magnetoencephalography (MEG) between 25 mTBI patients and 20 healthy controls. While VT induced no significant differences compared with resting state in either group, patients exhibited stronger attenuation of 8-14 Hz oscillatory activity during PASAT than healthy controls in the left parieto-temporal cortex (p ≤ 0.05). Furthermore, significant task-related modulation in the left superior frontal gyrus and right prefrontal cortex was detected only in patients. The ~10-Hz (alpha) peak frequency declined in frontal, temporal and parietal regions during PASAT compared with rest (p < 0.016) in patients, whereas in controls it remained the same or showed a tendency to increase. In patients, the ~10-Hz peak amplitude was negatively correlated with behavioral performance in the Trail Making Test. The observed alterations in the cortical oscillatory activity during cognitive load may provide measurable neurophysiological correlates of cognitive difficulties in mTBI patients, even at the individual level.

Language: en

Keywords

ADULT BRAIN INJURY; ASSESSMENT TOOLS; COGNITIVE FUNCTION; HUMAN STUDIES