Citation

Duke T, Mai M. J. Paediatr. Child Health 1999; 35(3): 319-320.

Affiliation

Department of Paediatrics, Goroka Base Hospital, Papua New Guinea. duke@global.net.pg

Copyright

(Copyright © 1999, John Wiley and Sons)

DOI

unavailable

PMID

10404461

Abstract

A child with meningitis who developed a psychosis 2 weeks after commencing treatment with antituberculous therapy is described here. The psychosis resolved with cessation of isoniazid, but the meningitis returned. The meningitis was treated by re-introduction of daily doses of isoniazid, but the psychosis recurred. Successful treatment of the meningitis, with minimal psychotic symptoms, eventually was achieved using isoniazid at 48 h dose intervals. The psychosis resolved completely after completion of therapy for tuberculous meningitis and cessation of isoniazid. This is the first case of isoniazid-associated psychosis reported in a child.

Language: en