Citation

Banki CM, Bissette G, Arato M, Nemeroff CB. Am. J. Psychiatry 1988; 145(12): 1526-1531.

Affiliation

Regional Neuropsychiatric Institute, Nagykallo, Hungary.

Copyright

(Copyright © 1988, American Psychiatric Association)

DOI

unavailable

PMID

3143269

Abstract

The concentration of thyrotropin-releasing hormone (TRH), a tripeptide (pyroglutamylhistidylprolin-amide), in the CSF of drug-free patients with DSM-III major depression, somatization disorder, and peripheral neurological disorders was measured with a sensitive and specific radioimmunoassay. The depressed patients had markedly higher CSF TRH concentrations than the other patient groups, and this finding could not be attributed to any demographic variables. The elevation of TRH in CSF provides further evidence of hypothalamic-pituitary-thyroid dysfunction in depression.

Language: en